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The antioxidant activity was determined using free radical scavenging assay and TLC-DB-DPPH * dot-blot test. Eleutherococcus senticosus (Rupr. et Maxim.). Jun 26, - This Pin was discovered by sofia garabedian. Discover (and save!) your own Pins on Pinterest. JOURNALS FREE ACCESS Download Meta RIS How to download Meta of polyherbal formulations containing Rhodiola rosea L. and Eleutherococcus senticosus Maxim. using rapid resolution liquid chromatography (RRLC). A. Panossian, G. Wikman, J. Sarris. Yaling Song, Jianming Zhou, Xuejing Wang, et al.

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Eleuthero is a small, woody shrub. People use the root of the plant to make medicine. Eleuthero is sometimes called "Siberian ginseng". But eleuthero is not related to true ginseng. Don't confuse it with American or Panax ginseng.

Eleuthero is often called an "adaptogen." This is a non-medical term used to describe compounds that might improve resistance to stress. But there is no good evidence showing that eleuthero has adaptogen-like effects.

Eleuthero is used for diabetes, athletic performance, memory and thinking skills (cognitive function), the common cold, and many other conditions, but there is no good scientific evidence supporting most of its uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for ELEUTHERO are as follows:

Possibly effective for

Common cold. Some research shows that taking a combination product containing eleuthero plus andrographis (Kan Jang, Swedish Herbal Institute) improves symptoms of the common cold. This product must be taken within 72 hours after symptoms begin. Some symptoms can improve after 2 days of treatment. But it usually takes days of treatment to get the most benefit.
Diabetes. Taking eleuthero extract can reduce blood glucose levels in some people with type 2 diabetes.
Genital herpes. Taking a specific eleuthero extract (Elagen) can reduce how often genital herpes flares up.

Insufficient evidence to rate effectiveness for

Athletic performance. Most research shows that taking eleuthero doesn't improve breathing or heart rate recovery after treadmill, cycling, or stair-stepping exercises. Taking eleuthero also doesn't improve endurance or performance in trained distance runners. But some research shows that taking powdered eleuthero might improve breathing and endurance while cycling.
Bipolar disorder. Taking eleuthero plus lithium for 6 weeks might improve symptoms of bipolar disorder about as well as taking lithium plus fluoxetine. It's unclear if taking eleuthero plus lithium works better than taking only lithium.
Chronic fatigue syndrome (CFS). Taking eleuthero by mouth doesn't seem to reduce symptoms of CFS any better than a placebo.
Memory and thinking skills (cognitive function). Early research shows that taking eleuthero might improve memory and feelings of well-being in some healthy, middle-aged people.
Nerve pain in people with diabetes (diabetic neuropathy). Early research shows that taking eleuthero extract may improve nerve pain by a small amount in some people with diabetes.
Hangover. Early research shows that taking eleuthero extract before and after drinking alcohol might relieve some hangover symptoms.
Quality of life. Some research shows that taking eleuthero can improve sense of well-being in people over years-old. But this effect doesn't seem to last for more than 8 weeks.
Stress. Early research shows taking eleuthero root doesn't reduce stress levels.
An inherited fever disorder (familial Mediterranean fever).
Altitude sickness.
Alzheimer disease.
Attention deficit-hyperactivity disorder (ADHD).
Bronchitis.
Chemotherapy side effects.
Fatigue.
Fibromyalgia.
Flu (influenza).
High cholesterol.
Motion sickness.
Osteoarthritis.
Osteoporosis.
Pneumonia.
Tuberculosis.
Upper airway infection.
Other conditions.

More evidence is needed to rate eleuthero for these uses.

Eleuthero contains many chemicals that affect the brain, immune system, and certain hormones. It might also contain chemicals that have activity against some bacteria and viruses.

Are there safety concerns?

When taken by mouth: Eleuthero is LIKELY SAFE for most adults when taken for up to 3 months. While side effects are rare, some people can have nausea, diarrhea, and rash. In high doses, eleuthero might cause nervousness and anxiety. There isn't enough reliable information to know if eleuthero is safe to use for longer than 3 months.

Special precautions & warnings:

Children: Eleuthero is POSSIBLY SAFE in teenagers (ages years) when taken by mouth for up to 6 weeks. There isn't enough reliable information to know if it safe when taken for longer than 6 weeks or when taken by children younger than 12 years of age.

Pregnancy and breast-feeding: There isn't enough reliable information to know if eleuthero is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: Eleuthero contains chemicals that might slow blood clotting. In theory, eleuthero might increase the risk of bleeding and bruising in people with bleeding disorders.

Heart conditions: Eleuthero might cause a pounding heart, irregular heartbeat, or high blood pressure. People who have heart disorders (e.g., "hardening of the arteries," rheumatic heart disease, or history of heart attack) should use eleuthero only under a healthcare provider's supervision.

Diabetes: Eleuthero might increase or decrease blood sugar. In theory, eleuthero might affect blood sugar control in people with diabetes. Monitor your blood sugar carefully if you take eleuthero and have diabetes.

Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Eleuthero might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use eleuthero.

High blood pressure: Eleuthero should not be used by people with blood pressure over / Eleuthero might make high blood pressure worse.

Mental conditions such as mania or schizophrenia: Eleuthero might make these conditions worse. Use with caution.

Are there interactions with medications?

Moderate: Be cautious with this combination.
Alcohol (Ethanol): Alcohol can cause sedative effects such as sleepiness and drowsiness. Eleuthero might also cause sleepiness and drowsiness. Taking large amounts of eleuthero along with alcohol might cause you to become too sedated.
Digoxin (Lanoxin): Digoxin (Lanoxin) helps the heart beat more strongly. One person had too much digoxin in their system while taking a natural product that might have had eleuthero in it. But it is unclear if eleuthero or other herbs in the supplement were the cause.
Medications changed by the liver (Cytochrome P 1A2 (CYP1A2) substrates): Some medications are changed and broken down by the liver. Eleuthero might decrease how quickly the liver breaks down these medications. Taking eleuthero along with medications that are changed by the liver might increase the effects and side effects of some medications. Before taking eleuthero, talk to your healthcare provider if you take any medications that are changed by the liver.

Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline (Slo-bid, Theo-Dur, others), zileuton (Zyflo), zolmitriptan (Zomig), and others.
Medications changed by the liver (Cytochrome P 2C9 (CYP2C9) substrates): Some medications are changed and broken down by the liver. Eleuthero might decrease how quickly the liver breaks down these medications. Taking eleuthero along with medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking eleuthero, talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include amitriptyline (Elavil), diazepam (Valium), zileuton (Zyflo), celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), estradiol (Estrace), tacrine (Cognex), verapamil (Calan), and others.
Medications for diabetes (Antidiabetes drugs): Eleuthero might affect blood sugar by lowering blood sugar levels. Diabetes medications are also used to lower blood sugar. Taking eleuthero along with diabetes medications might cause your blood sugar to go too low or cause your diabetes medication to be less effective. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications moved by pumps in cells (Organic anion-transporting polypeptide substrates): Some medications are moved by pumps in cells. Eleuthero might change how these pumps work and decrease how much of some medications get absorbed by the body. This could make these medications less effective. Some of these medications that are moved by pumps in cells include bosentan (Tracleer), celiprolol (Celicard, others), etoposide (VePesid), fexofenadine (Allegra), fluoroquinolone antibiotics, glyburide (Micronase, Diabeta), irinotecan (Camptosar), methotrexate, nadolol (Corgard), paclitaxel (Taxol), saquinavir (Fortovase, Invirase), rifampin, statins, talinolol, torsemide (Demadex), troglitazone, and valsartan (Diovan).
Medications moved by pumps in cells (P-glycoprotein substrates): Some medications are moved by pumps into cells. Eleuthero might make these pumps less active and increase how much of some medications get absorbed by the body. This might increase the side effects of some medications.

Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.
Medications that decrease the immune system (Immunosuppressants): Some medications are moved by pumps into cells. Eleuthero might make these pumps less active and increase how much of some medications get absorbed by the body. This might increase the side effects of some medications.

Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs): Eleuthero might slow blood clotting. Taking eleuthero along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Sedative medications (CNS depressants): Eleuthero might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking eleuthero along with sedative medications might cause too much sleepiness.

Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.
Minor: Be watchful with this combination.
Medications changed by the liver (Cytochrome P 2D6 (CYP2D6) substrates): Some medications are changed and broken down by the liver. Eleuthero might decrease how quickly the liver breaks down these medications. Taking eleuthero along with medications that are changed by the liver can increase the effects and side effects of your medication. Before taking eleuthero, talk to your healthcare provider if you take any medications that are changed by the liver. However, this interaction is not verified with certainty in humans yet.

Some medications that are changed by the liver include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.
Medications changed by the liver (Cytochrome P 3A4 (CYP3A4) substrates): Some medications are changed and broken down by the liver. Eleuthero might decrease how quickly the liver breaks down these medications. Taking eleuthero along with medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking eleuthero, talk to your healthcare provider if you are taking any medications that are changed by the liver.

Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

Are there interactions with herbs and supplements?

Herbs and supplements that might lower blood sugar: Eleuthero might lower blood sugar. Taking eleuthero along with herbs and supplements that might also lower blood sugar might cause your blood sugar to go too low or cause your diabetes medication to be less effective. Some of these products include bitter melon, ginger, goat's rue, fenugreek, kudzu, gymnema, and others.
Herbs and supplements that might slow blood clotting: Eleuthero might slow blood clotting. Taking eleuthero along with herbs or supplements that also slow clotting might increase the chances of bruising and bleeding. Some of these herbs and supplements include angelica, clove, danshen, fish oil, garlic, ginger, Panax ginseng, red clover, turmeric, vitamin E, and others.
Herbs and supplements with sedative properties: Eleuthero might act like a sedative. That is, it might cause sleepiness and drowsiness. Taking eleuthero along with other herbs that also act like sedatives might increase its effects and side effects. Herbs with sedative effects include calamus, California poppy, catnip, German chamomile, gotu kola, hops, Jamaican dogwood, kava, lemon balm, sage, St. John's wort, sassafras, skullcap, valerian, wild carrot, wild lettuce, and others.

Are there interactions with foods?

There are no known interactions with foods.

The following doses have been studied in scientific research:

BY MOUTH:

For the common cold: mg of a specific combination product (Kan Jang, Swedish Herbal Institute) containing eleuthero plus andrographis extract, three times daily for 5 days.
For diabetes: mg of eleuthero extract, standardized to contain eleutheroside E and B %, daily for 3 months.
For genital herpes: mg of eleuthero extract standardized to contain eleutheroside E %, daily for 3 months.

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To learn more about how this article was written, please see the Natural Medicines Comprehensive Databasemethodology.

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